EFFECTS OF STRONTIUM ASSOCIATED WITH BIOMATERIALS ON THE MODULATION OF BONE METABOLISM: AN INTEGRATIVE REVIEW

João Paulo Tavares LINHARES, Igor Iuco CASTRO-SILVA

Resumo


Bone regeneration remains a clinical challenge despite the widespread availability of implantable devices. Incorporating the strontium cation—as a substitute for calcium—into biomaterials has attracted attention due to its bioactivity and sustained release properties. This integrative review aimed to analyze the effects of incorporating strontium into biomaterials used for bone regeneration. A search of the PubMed and BVS (LILACS and SciELO) databases identified original full-text studies published between 2020 and 2025 in Portuguese, English, or Spanish, including preclinical studies on strontium-functionalized biomaterials. The primary outcomes evaluated were the intrinsic characteristics of the bioactive-biomaterial combination and the modulation of bone metabolism. Among the 15 studies utilizing in vitro and in vivo models, strontium was incorporated into biomaterials via doping, adsorption, or ionic substitution, with molar concentrations ranging from 0.26 to 50 mol%, atomic percentages from 1 to 90 at%, or weight percentages from 15 to 37 wt%. Strontium was more frequently associated with ceramics and bioglasses than with composites or polymers. Regarding biomarkers involved in cellular physiology and bone matrix formation and maturation, a dual benefit for bone gain was observed: stimulation of osteoblast-mediated anabolism and angiogenesis, alongside the reduction of osteoclast-mediated catabolism and oxidative stress. Despite promising results regarding the modulation of bone metabolism, the wide range of concentrations and applications in animal models necessitates further in-depth testing of the safety and efficacy of strontium-incorporated biomaterials in humans to standardize clinical protocols for bone regeneration.

Keywords: Strontium. Biocompatible Materials. Bone Regeneration.


Texto completo:

PDF

Referências


CASTRO-SILVA, I. I. et al. Pesquisa odontológica brasileira em regeneração óssea guiada: um estudo bibliométrico de quatro décadas. Research, Society and Development, v. 10, n. 2, p. e25510212504, 2021. http://dx.doi.org/10.33448/rsd-v10i2.12504.

CHAN, R. S. M. et al. Engineered 3D-printable nanohydroxyapatite biocomposites with cold plasma-tailored surface features to boost osseointegration. ACS Applied Materials & Interfaces, v. 17, n. 16, p. 23522-23535, 2025. https://doi.org/10.1021/acsami.4c22032.

CHEN, D.; ZHAO, J.; JIANG, X. Synthesis and characterization of silver substituted strontium phosphate silicate apatite using solid-state reaction for osteoregenerative applications. Bioengineered, v. 12, n. 1, p. 1111-1125, 2021. https://doi.org/10.1080/21655979.2021.1899670.

CIRILLO, M. et al. Strontium substituted hydroxyapatite with β-lactam integrin agonists to enhance mesenchymal cells adhesion and to promote bone regeneration. Colloids and Surfaces B Biointerfaces, v. 200, p. 111580, 2021. https://doi.org/10.1016/j.colsurfb.2021.111580.

COSTA, J. D. et al. Evaluation of toxicity, local biocompatibility, biodegradation, and systemic metabolism of cellulose/alginate/strontium apatite membranes implanted

subcutaneously in mice. Acta Cirúrgica Brasileira, v. 40, p. e401925, 2025. https://doi.org/10.1590/acb401925.

GALVÁN-CHACÓN, V. P. et al. Droplet microfluidics as a tool for production of bioactive calcium phosphate microparticles with controllable physicochemical properties. Acta Biomaterialia, v. 128, p. 486-501, 2021. https://doi.org/10.1016/j.actbio.2021.04.029.

JIANG, S. et al. Synergistic effect of micro-nano-hybrid surfaces and Sr doping on the osteogenic and angiogenic capacity of hydroxyapatite bioceramics scaffolds. International Journal of Nanomedicine, v. 17, p. 783-797, 2022. https://doi.org/10.2147/IJN.S345357.


Apontamentos

  • Não há apontamentos.


JNT - Facit Business and Technology Journal

ISSN 2526-4281